Tested with MooTools 1.2
Set http:// links to open in a new window automatically.
window.addEvent('domready', function() {
$$('a[href^=http://]').setProperty('target', '_blank');
});
If for some reason you have all of your links with http:// in them, you will need to use something a bit more complicated. However, I do believe you should look into sorting out your URLs.
window.addEvent('domready', function() {
var domain_name = 'http://www.yourdomain.com/';
$$('a').each(function(el) {
if(el.href.substring(0, a.length - 1) != domain_name) {
el.setProperty('target', '_blank');
}
});
});